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These results indicated that GSH and -EC were more stable at 25 C than at 37 C, suggesting that higher productivity of -EC may be obtained at 25 C than at 37 C, despite the reduced reaction rate

Because you might need to take care of that before taking care of this

Spinal stenosis Narrowing of the spinal canal

After overdosing, when the glucuronidation and sulfation pathways are saturated, the rest of the dose is oxidized by microsomal cytochrome P450 to a toxic product N -acetyl- p -benzoquinone imine (NAPQI)

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V., & Thomatieli-Santos, R