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it's about not needing it if you're a beginner or sedentary individual

In this 2008 study, intrathecal (i.t.) administration of ALX5407 (doses of 10, 50, and 100 g) resulted in significant analgesic effects, with an increase in mechanical pain thresholds observed up to 240 min after administration

10.3877/cma.j.issn.1673-5250.2021.04.008(in Chinese)

So I'll try to keep it brief, but I think it all started with my mom, honestly telling me from the time I can remember that I'm going to be a brain surgeon and obviously I'm not a brain surgeon, but I am obsessed with the brain and the mind, and the body, and health, and all of this stuff and I really think that kind of laid the foundation, right

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Y.et al (2016)