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A 2020 preclinical study evaluating gabapentin in an experimental colitis model demonstrated: Reduced visceral hypersensitivity Decreased inflammatory signaling Reduced mast cell density and activation markers in colonic tissue Downregulation of pro-inflammatory pathways (including NF-B signaling) Mast cells and enteric nerves communicate bidirectionally in the gut

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Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors

[DOI] [PubMed] [Google Scholar] Urata Y, Yamamoto H, Goto S, Tsushima H, Akazawa S, Yamashita S, Nagataki S, Kondo T