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With NAD+ deficiency DNA damage accumulates and leads to genomic instability, one of the main hallmarks of aging

Yoneshiro T, et al ., BCAA catabolism in brown fat controls energy homeostasis through SLC25A44, Nature , 2019, 572, 614

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The cause of CoQ10 deficiency associated with AM therapy is as yet unknown, although it may be caused by the increase in OS associated with this pharmacotherapy [50]

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