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doi: 10.3389/fphar.2022.862763 Received 26 January 2022 Accepted 04 April 2022 Published 26 April 2022 Volume 13 - 2022 Edited by Oliver Grundmann, University of Florida, United States Reviewed by Julio Plaza-Diaz, Childrens Hospital of Eastern Ontario (CHEO), Canada Wuwen Feng, Chengdu University of Traditional Chinese Medicine, China Jailane Souza Aquino, Federal University of Paraba, Brazil Updates Copyright 2022 Cao, Du, Zhai, Li, Meng, Shao and Gao

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Consequently, researchers require improved receptor-selective analogues, advanced pharmacologic tools, and genetic knockout systems to isolate MC4-specific signaling contributions while minimizing cross-reactivity between receptor subtypes

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