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Published 2026-1-14 Rationale: Androgen deprivation therapy (ADT) is the cornerstone of prostate cancer (PCa) treatment

Frison-Norrie et al

Taken together, despite an occasional study to the contrary, the literature strongly supports important roles for GGT and cysteine S -conjugate -lyases in promoting the nephrotoxicity of halogenated alkenes

In contrast to glutathione, NAC is efficiently transported into the cell where it is readily converted to cysteine for glutathione synthesis

No severe adverse events were observed, which supports the conduct of further Phase III trials to validate longterm efficacy and safety

When combining CDs with cosolvents, cosolvents increase free drug concentration, which increases the CDs' complexation drive 3