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A randomised placebo controlled exploratory study of vitamin B-12, lofepramine, and L-phenylalanine (the Cari Loder regime) in the treatment of multiple sclerosis

Malecki, J.M., et al

3.3 Glutaminase inhibition affects mitochondrial respiration and energy metabolism in CLL cell lines but can be successfully compensated for by glycolysis In the HG-3 and MEC-1 cell lines, CB-839 treatment caused dose-dependent decreases in the OCR, including the basal OCR, maximal respiration rate, and spare respiratory capacity

The sublingual route ensures that glutathione is delivered directly into the bloodstream, bypassing the gastrointestinal system where it may be broken down, which could render it less effective

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