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Furthermore, CSCs seem to run futile cycles metabolically (i.e., activating lipogenesis and fatty acid oxidation and OXPHOS simultaneously), because these processes are not absolutely efficient

doi: 10.1159/000212694

10.1016/j.bbrc.2018.12.144 Biochem

Robison ATR, Sturrock GR, Zaengle-Barone JM, Wiebelhaus N, Dharani A, Williams IG, et al

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Interestingly, although the Long Island Breast Cancer Study yielded an overall negative result, in a subgroup analysis from this study, nulliparous women homozygous for the Leu allele had significant increased risk compared to homozygous Pro parous women