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The trend is real but we cannot point to one proven reason

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Because B12 is water soluble, the body doesnt store large amounts of it long-term the way it stores fat-soluble vitamins, which is one reason ongoing dietary intake or supplementation matters for some people more than others

If you did not purchase this container with your medication, you can use a hard-plastic container with a screw-on top such as a clothing softener or hard plastic detergent bottle

2015 NNMT consumes SAM as a methyl donor, competing with DNA and histone methyltransferases

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 48 (12), 13301337 (2005)