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In summary, schisandrin lignans appear to protect dopaminergic neurons by a combination of antioxidant, anti-excitotoxic, anti-inflammatory, and pro-autophagic mechanisms, making them interesting candidates for further neuroprotective research

Hepatocyte-specific Mas activation enhances lipophagy and fatty acid oxidation to protect against acetaminophen-induced hepatotoxicity in mice

By the same token, the bypass of phosphofructokinase-1 through fructose catabolism which negates the Pasteur effect and contributes to the Warburg effect should also be considered when focusing on tumor fuel catabolism, provided of course, that the pertinent tumor expresses sufficient levels of fructokinase (Fig

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Reactive oxygen species (ROS)

Our data suggest that glutathione metabolic genes are transcriptionally regulated to maintain their specialized or ubiquitous functions