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PMCID: PMC9785784

In a healthy lean Phase 1b group, the same dose raised heart rate by about 10 bpm, with a peak near 15 to 20 bpm around days 4 to 6

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For FA, the continuous increase in the RD may have a main and greater impact on FA, and such factors like reduction of myelin sheath integrity and fiber density, and edema may ultimately have led to the destruction of microscopic integrity of tissues 37,38 , which was manifested as a continuous decrease in FA from the 4w group to the 6w group 22

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