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In recent in vitro assays performed by our group [32], we showed that H 2 O 2 -induced oxidative stress triggered the binding of Prx2 and GPx to RBC membrane

Resident macrophages in the cochlear blood-labyrinth barrier and their renewal via migration of bone-marrow-derived cells

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[46] The data from the ASCEND study were also pooled with data from the two CAPACITY studies in a pre-specified analysis which showed that pirfenidone reduced the risk of death by almost 50% over one year of treatment

Hence, combination therapies seem to be potentially useful and valuable approaches to prevent CIPN development or treat its symptoms

Acts as a force multiplier for other antioxidants like Vitamin C and E, regenerating them for continued use