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Ca 2+ is not metabolized and an overload of mitochondrial Ca 2+ may break down the electrochemical proton gradient resulting in a deficit of ATP followed by necrosis [89]

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[DOI] [Google Scholar] 146.Barnes T.M., Mijaljica D., Townley J.P., Spada F., Harrison I.P

A noteworthy question, however, is whether the sulfating activity of another SULT2B1 variant, SULT2B1a, can be influenced by nonsynonymous coding SNPs (cSNPs) in SULT2B1 , thus leading to distinct physiological and pathological effects related to steroid metabolism in different individuals