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It also suppresses HIF-1, accompanied by decreased levels of lactate and other important metabolites that are involved in GSH synthesis [219]

As the regulatory network of GCN5L becomes more comprehensive, it shows great potential as an acetylation switch target in metabolic disorders, cancer immunotherapy, and neurodegenerative disorders

It has been observed that frataxin deficiency results in iron accumulation within mitochondria and increased sensitivity to oxidative stress

10.1097/MAT.0000000000002231 12 BalistrieriA.MakinoA.YuanJ

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[DOI] [PMC free article] [PubMed] [Google Scholar] 14.Evaluation of pro-oxidant-antioxidant balance (PAB) and its association with inflammatory cytokines in polycystic ovary syndrome (PCOS) Artimani T, Karimi J, Mehdizadeh M, et al
