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Description
Olefin cyclopropanation via carbene transfer catalyzed by engineered cytochrome P450 enzymes
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Abstract Bipolar disorder (BD) is characterized by extreme mood swings ranging from manic/hypomanic to depressive episodes
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By blocking NNMT, it prevents the methylation reaction that depletes SAM and nicotinamide, thereby preserving both cofactors and restoring the metabolic machinery that NNMT overexpression had suppressed
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The antioxidant response as a drug target in diabetic neuropathy
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10.3390/biomedicines11061610 204 RosenblumD.GutkinA.KedmiR.RamishettiS.VeigaN.JacobiA
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doi: 10.1186/1471-2229-8-22
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