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J Biol Chem 280: 3225432261 Pollard MG, Travers KJ, Weissman JS (1998) Ero1p: a novel and ubiquitous protein with an essential role in oxidative protein folding in the endoplasmic reticulum

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Targeting antioxidants specifically to the mitochondria is of particular interest, given that more than 80% of reactive oxygen species (ROS) are generated at this site