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The oxidized form is reconverted into GSH by the NADPH-dependent enzyme glutathione reductase (GR) [3]
However, FOXO4-DRI treatment significantly reduced the expression of these detrimental SASP factors and, critically, restored the proliferation of GC-1 spg cells in the co-culture system, as evidenced by CCK-8 assays and PCNA expression, without inducing apoptosis in the spermatogonia
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BPC-157 reduced Ki-67 markers in melanoma cells, indicating suppressed proliferation rather than enhanced growth
