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Per BNF and BSH guidance: For confirmed deficiency without neurological involvement: 1 mg IM on alternate days for two weeks, then 1 mg every two to three months for maintenance

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Prior to eventual internalization by distant immune cells, the formation of MVs, which also contain important immune-cell receptors and inhibitory complement receptors, may contribute to an immune or tolerogenic microenvironment for MM cells in the bone marrow (BM) niche [25] [26]