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Description
LA additionally enhances nuclear NF-E2-related factor 2 (Nrf2) and downstream targets by activating the SIRT1 pathway
Glutathione is usually referred to as the body's master anti-oxidant
An Evolving Understanding of the S-Glutathionylation Cycle in Pathways of Redox Regulation
Several aspects still need to be clarified: (i) Is this mouse model reliably recapitulating the human scenario of development of autoimmune thyroid diseases, known to have a strong component of genetic predisposition and gender dependence
They were weighed to monitor health effects
The specificity and effective in vivo concentrations of many natural products or small molecule agonists are debatable, with some effects possibly stemming from their broad-spectrum antioxidant capacity rather than genuine Nrf2-specific action
