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Similarly, sildenafil reduces oxidative stress in the smooth muscle of rabbit penile blood vessels exposed to substances which induce ROS production such as TNF-, nicotine, homocysteinecopper combination, and the thromboxane A2 mimic [146,199,200]

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Reported Effects Mild and infrequent effects reported in research include transient nasal irritation (intranasal administration), mild headache, and short-lived changes in alertness