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The epithelial tight junction proteins, the most apical component of epithelial intracellular junctions, equip IECs with this function, which seals the paracellular space between the cells and tightly restricts the transport of hydrophilic molecules 22,23,24

323 A number of secondary outcomes from the TRAVERSE trial have since been examined, showing positive effects from TRT: Reduced blood pressure, with a greater effect in those with higher baseline blood pressure 324