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According to the NIH Office of Dietary Supplements, absorption issuesnot intake aloneare a leading cause of low B12 levels

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The exact mechanisms, sites, and pathways of action of CNS-targeted IN therapeutics are still under debate, but IN drugs and tracer molecules appear to be distributed throughout the brain via the CSF and extracellular fluid of the perivascular spaces around the olfactory and trigeminal nerves [14]
