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This makes combination therapy particularly attractive in resistant cases or where long-term results are needed

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During adulthood, serum B12 concentrations tend to decline with age, especially in the elderly (Wahlin et al., 2002), probably arising from the gradual decrease in both gastric acidity and intrinsic factor production that occurs with aging (Asselt et al., 1998

For laboratory use, it may be reconstituted with bacteriostatic water or another appropriate solvent according to established research protocols