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Additionally, studies have shown that GPX4 expression is reduced to varying degrees in both cells and kidneys in DKD models, weakening cellular resistance to oxidative stress and promoting lipid peroxidation, ultimately leading to ferroptosis ( Recent studies using cellular and animal models have confirmed that inhibiting ferroptosis in renal cells slows the progression of DKD

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PMID: 15570120 Singh, K., Vaccaro A.R.., Eichenbaum, M.D., Fitzhenry, L.N.: The Surgical Management of Thoracolumbar Injuries

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But most of the affected study holds up