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Extensive research has established glutathione peroxidase 4 (GPX4) as a critical regulator in the pathogenesis of multiple pathological conditions, including osteoarthritis 35 ,cancers 47 , and liver disease 48

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Senescent and apoptosis-resistant lung fibroblasts have been shown to contribute to the persistence and progression of fibrosis [15]

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Flavonoids, such as quercetin and catechins, are known for their ability to scavenge free radicals and modulate oxidative stress pathways [195]

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