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Across GLP-1 trials, roughly 60% of lost weight returns within a year and about 75% over the longer regain curve

10.1089/ars.2016.6755 36 GiulianteR.SartiniD.BacchettiT.RocchettiR.KltingI.PolidoriC.et al (2015)

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These studies suggest that strategies combining NAD + boosting with inhibitors of NAD + -consuming enzymes could be a promising approach to mitigate axon degeneration