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Bayati, A., Kumar, R., Francis, V
Our attempts to obtain X-ray co-crystal structures of TGR and inhibitors resulted in structures with no detectable density of the inhibitors, possibly owing to the limited solubility of the compounds in the crystallization conditions
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Through a process catalyzed by the enzyme Glutathione S-Transferase (GST) , glutathione physically attaches (conjugates) itself to these dangerous electrophilic xenobiotics and intermediate metabolites
Anal Biochem 119:281285 Facompre ND, Sinha I, El-Bayoumy K, Pinto JT, Sinha R (2012) Remarkable inhibition of mTOR signaling by the combination of rapamycin and 1,4-phenylenebis(methylene) selenocyanate in human prostate cancer cells
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