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Pubertal delay and reduced pubertal growth spurts are characteristic findings of longstanding ESRD and probably result from the reduced release of hypothalamic gonadotropin-releasing hormone (GnRH) and decreased circulating levels of bioactive luteinizing hormone (LH) due to CKD-related inhibitory factors such as angiotensin II 29

Studies demonstrate Epithalon's ability to influence gene expression and protein synthesis during neurogenesis

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