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Effects of chronic hyperinsulinemia in insulin-resistant patients

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Most cells are capable of glutathione synthesis especially hepatocytes since glutathione reductase enzyme is present in these cells

found that Gyejibongnyeong-Hwan (GBH) induces apoptosis by elevating mitochondrial ROS levels, promoting p53, caspase-3, and caspase-9 expression, and increasing the Bax/Bcl-2 ratio, demonstrating GBH's potential as a therapeutic agent for uterine fibroids [95]

Additionally, we discovered that a GSH threshold of 10.2 nmol/mg effectively differentiates resistant cells from sensitive cells, with an AUC of 0.913, providing a robust distinction between chemotherapy-resistant and sensitive patients

[DOI] [PubMed] [Google Scholar] 24.Hasegawa T.Tyrosinase-expressing neuronal cell line as in vitro model of Parkinsons disease