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[7] The effects of high-dose NAD+ on a developing fetus or nursing infant have not been studied, so the therapy is avoided entirely in these situations out of caution

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Individuals with a history of thromboembolic disorders should also be carefully evaluated prior to treatment, especially when HCG is used as part of ovulation induction protocols in women, as it may increase thrombotic risk through hormone elevation

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There can be an immediate solution, along with its modulatory controlling effect described above for VEGF (see above, Section 2.3 and Section 2.4), as the promoter of the egr-1 gene also mediates angiogenesis [158,159] and induces cytokine and growth factor generation and early extracellular matrix (collagen) formation

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