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While the activity of NHR-49 is regulated at multiple levels including cofactor interactions, heterodimerization with other nuclear receptors, and isoform-specific subcellular localization 23,42,45,46,47,48 , nuclear hormone receptors are classically defined as ligand-regulated transcription factors 49,50,51,52,53

In the worm, a rise in temperature is detected with the aid of specific thermosensory neurons that convert warming into electrical signals transducted through a neuronal circuit to orchestrate a cellular response [4,6]

ND2, NADH Dehydrogenase Subunit 2

PLoS Genet 11:e1005265 Braeckman BP, Houthoofd K, Vanfleteren JR, 2009

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