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Apart from low doses, when opting for protocols with weekly macrodoses of supplementation or booster doses, we must provide a very high intake of B12 to ensure that we cover the absorption of a small but sufficient fraction, even at the expense of the vast majority of the B12 in the supplement not being utilized and being eliminated due to the lower absorption efficiency found with this route, as it is not dependent on the intrinsic factor

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However, use of lithium heparin should be avoided, as this anticoagulant may produce gelatinous serum and elevated B12 concentrations

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Mutational analysis of the hormone-sensitive lipase translocation reaction in adipocytes