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Renal OCTN2 expression and activity increase when the carnitine concentration is reduced in the plasma and/or glomerular filtrate, whereas OCTN2 mRNA expression levels remain unchanged in the gut, liver, or skeletal muscle [254], highlighting the central role of the kidney in maintaining carnitine homeostasis

When uncertainty exists, biopsy provides definitive diagnosis and excludes melanoma

[DOI] [PubMed] [Google Scholar] 141.De Hert M, Detraux J, van Winkel R, Yu W, Correll CU

doi:10.1016/j.addr.2009.06.009 Foster DW

This increases melanosome production and transfer to keratinocytes, where melanin absorbs UV radiation

LoPresti ST, Arral ML, Chaudhary N, Whitehead KA