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Renjith, I find the 15-PGDH inhibition approach particularly compelling because it targets endogenous chondrocytes rather than relying on stem-cell therapy, positioning it as a potential first-in-class disease-modifying therapy for osteoarthritis

This result is consistent with our previous findings, in which ER stress signaling in hepatoma cells was diminished by etomoxir, by inhibition of -oxidation with a separate agent, and by knockdown of CPT1 (Tyra et al., 2012)

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Cancer Res (2001) 61(23):8498503

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