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The induction of protective cellular pathways, such as those involving vitagenes like sirtuins (a class of HDACs), has been proposed as a related neuroprotective strategy observed in other auditory pathologies like Menieres disease, which is characterized by tinnitus and considered a model of cochlear neurodegeneration (Scuto et al., 2020)

these were patients that have early disease, given the inclusion criteria was patients who exhibited their first non-Raynaud symptom no earlier than 60 months prior to recruitment in the trial

Iron (Fe)-redox dysregulation (FeRD) During SARS-CoV-2 infection, free iron released into the circulation induces inflammation of alveolar macrophages and causes oxidative damage to the lungs 144

MBS2500392), interleukin 1 beta (IL-1 , catalog No
4-Coumarate 3-hydroxylase in the lignin biosynthesis pathway is a cytosolic ascorbate peroxidase
