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Psychopharmacology 241, 97107

& Krupenko, N

[DOI] [PubMed] [Google Scholar] 106.Hause B., Rajgarhia V., Suominen P

GTP-bound RAS (activated form) binds to RAF proteins (c-RAF, BRAF, and ARAF) and induces conformational alternations to dimerize RAF, which is activated and turns on the kinase cascade [110]

In the Krebs cycle, adenosylcobalamin can induce the accumulation of succinate, an antagonist of histone and DNA demethylation reactions catalyzed by enzymes of the 2-oxoglutarate-dependent dioxygenase family, which may favor the activation or inhibition of gene expression ( Figure 5 )

In summary, the evidence demonstrates the broad genomic distribution and diverse regulatory functions of VDRs, which influence gene expression, disease pathogenesis, and genetic integrity