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Reactive oxygen species including hydrogen peroxide are also involved in other cellular processes, such as mitochondrial function and growth factor-mediated cell signaling, thus GPx may also affect such aspects of cellular function 60

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Indeed, human patients with -thalassemia show increased flow-mediated dilation without differences in anemia or hemolysis, suggesting that -globin control of vascular tone is a conserved mechanism from mouse to human (121)

Of note, through histopathological and immunofluorescence analyses of immune cell subsets, we confirmed that lowering oxalate via AGXT overexpression or pharmacological inhibition of LDHA and GO reduces steatohepatitis aligned with the decrease in distinct subsets of recruited monocyte-derived macrophages (CCR2 + and TREM2 + macrophages) that are known to infiltrate the liver in MASH and form crown-like structures surrounding hepatocytes with large lipid droplets 49

Anbualakan K, Tajul Urus NQ, Makpol S, Jamil A, Mohd Ramli ES, Md Pauzi SH, Muhammad N