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Additionally, the spatio-temporal nature of CICD pathways necessitates biomarkers to reflect the time and intensity of activity in pathways (Gim et al

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Indeed, real-time imaging in the presence of a Caspase-3/7-activatable dye showed FOXO4-DRI to specifically induce Caspase-3/7 activation in senescent, but not control, cells (Fig

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