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Results Molecular analysis reveals structural stability of GRLX and pKa of individual cysteines Given the previous observations that GLRX can be inactivated via an oxidative mechanism 8,23 , herein we sought to investigate the relative vulnerability of each of the individual cysteines towards GSSG, a model glutathionylating agent, or H 2 O 2 and their contribution to oxidative inactivation
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J Biol Chem 2015;290:2312434
This metabolic pathway has important clinical implications for drug-drug interactions
10.1002/jcc.21334 47 TsegayeA.WubieA
