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The competition between NAD + salvage and the methylation of NAM suggests that NNMT may reduce the oxidation of fuel and increase the storage of fat by regulating the formation of NAD + (Trammell and Brenner, 2015)

From boosting energy levels to enhancing brain and nervous system function, their benefits are wide-ranging when used appropriately

doi: 10.1182/blood-2009-06-189209

Titration upward (where applicable) is provider-directed based on response and side-effect profile

5-Amino-1MQ inhibits the NNMT enzyme to theoretically raise NAD+ levels and improve insulin sensitivity, but evidence is limited to preclinical animal studies only