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Our genetic and pharmacological inhibition of LIPE strongly suggests that lowering unsaturated FA levels by slowing the lipase-mediated lipid degradation process represents a novel therapeutic strategy, a finding that stands in mechanistic agreement with our earlier work on SCD inhibition and augments the relevance of targeting FA metabolism to achieve S homeostasis

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Emmerich J., Beg O.U., Peterson J., Previato L., Brunzell J.D., Brewer H.B., Santamarina-Fojo S

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