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1 Introduction Lenvatinib is a small-molecule tyrosine kinase inhibitor (TKI) that targets multiple receptors, including vascular endothelial growth factor receptors (VEGFRs) 13, fibroblast growth factor receptors (FGFRs) 14, and platelet-derived growth factor receptor (PDGFR) and (Rinninella et al., 2020)