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The first is the antioxidant barrier: polyphenols establish antioxidant defense by activating the Nrf2 signaling pathway, and Nrf2 upregulates the expression of HO-1, SOD-1, NQO-1 and other oxidative genes, so as to increase the number of antioxidant enzymes (SOD/CAT/GPX/GSH), and to neutralize cisplatin-induced reactive oxygen species (ROS) and reactive nitrogen species (RNS)

How GHK-Cu Actually Works Most peptides bind a receptor

The stress protein TP53INP1 plays a tumor suppressive role by regulating metabolic homeostasis

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The glutathione system comprises the enzymes that synthesize glutathione within a cell as well as dedicated enzymes that use glutathione (GSH) as the means to exert antioxidant effects