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The neuroprotective effects of paeoniflorin against MPP+-induced damage to dopaminergic neurons via the akt/Nrf2/GPX4 pathway

Serotonin is synthesized from tryptophan through the action of tryptophan hydroxylase, which converts tryptophan into 5-hydroxytryptophan, followed by decarboxylation to produce serotonin

doi: 10.2460/javma.229.11.1761

19, 20 The p.Asp444His variant in trans with a severe BTD pathogenic variant is associated with partial biotinidase deficiency, while in cis with p.Ala171Thr (i.e., as the double mutant p.[(Ala171Thr);(Asp444His)]), results in a profound biotinidase deficiency allele

In human lens epithelial samples, significantly elevated Fe 2+ and lipid peroxidation levels were detected in HMC compared with ARC (Fig
doi:10.1212/01.wnl.0000325581.26991.f2
