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Archived from the original on 4 September 2019

This heterologous desensitization characterized by an uncoupling of G proteins from DOR is neither associated with modifications in receptor number nor in their phosphorylation but involves several kinases [cAMP-dependent protein kinase (PKA), MAP kinases/ERK kinase 1 (MEK1) and phosphoinositide-3 kinase (PI3K)] that could phosphorylate signaling proteins (Xu et al., 2013)

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doi: 10.18632/aging.102944

Rules of recruitment for Th1 and Th2 lymphocytes in inflamed liver: a role for alpha-4 integrin and vascular adhesion protein-1

With this knowledge in hand, a library of N -acyl-Tyr-Ile-(6) amino-hexanoic amide analogs was screened for their capacity to potentiate the biologic activity of HGF