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Thirdly, comprehensive characterization of NPs dose-response relationships is essential to establish optimal therapeutic thresholds while mitigating potential long-term toxicity and safety risks

The results of this study demonstrate that the PDIiNOSNOROS signaling axis plays a pivotal role in BSO-induced ferroptosis in a cell culture model, and also offer strategies for the selective manipulation (enhancement or suppression) of ferroptosis by targeting PDI or its downstream signaling elements

The following insights shed some light on why it happens

doi: 10.1007/s12017-018-8518-6

Based on the threshold effect of autophagy regulating cell death/survival, excessive activation of autophagy can promote cell death when it exceeds a certain threshold, and it may be more promising to play a positive role of autophagy in RT [27]

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