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In the work by Veldhuis et al., each peptide produced a large outcome on its own

Yet, the short duration of the study did not permit a conclusion on whether the lowering of homocysteine through B-vitamin supplementation could have long-term benefits on bone strength and fracture risk (119)

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[5] Pyridoxine (vitamin B) is converted to pyridoxal-5-phosphate, a coenzyme for over 100 enzymes in amino acid metabolism

The animal data offers a partial explanation

These peptides work through entirely different biological pathways, and understanding those differences is the key to optimizing your protocol