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A mouse model with exons 3 and 4 deletions of the Mecp2 gene ( Mecp2B ) appears to have elongated mitochondria in the hippocampal axons and dendrites [365], and increased oxidative stress seen by increased fluorescence of the redox probe roGFP1 both in the mitochondria and cytosol [366]

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Failure to treat chronic constipation (long-lasting symptoms of constipation) can lead to serious complications such as changes in the gut microbiome, fecal impaction, and anal fissures (small tears in the anus due to straining with dry stools)

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