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Heterogeneity in NMA was high (between-study variance=5.75, I 2 =96%) compared also to the Rhodes et al 22 empirical distribution (median 0.05, 95% range: 0.00 7.56)

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One retrospective study of intra-articular knee injections reported symptomatic improvement lasting over six months following a single injection in 7 of 12 patients, suggesting potential for sustained effects beyond active treatment periods