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Studies, including our own lab, have shown that neutrophils were constitutively active in T2D subjects and showed reduced response to LPS/infections to form NETs [7]

Age-related imbalances in this ratio reduce mitochondrial function, which leads to lower ATP production and more reactive oxygen species (ROS) [8]

Therefore, our studies provide a novel strategy against RAS-bearing cancers that warrants further mechanistic and translational investigation

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